I read somewhere that...

It never fails:  Several days after I’ve read some interesting research, that same subject comes up, but I can’t retell all the study details as clearly as I would like to.

This is a list of some interesting research studies that I have reviewed. I will give the study and where to find it for those who care to investigate further.

6/22/11 High-dose statin use linked with diabetes."Data from an animal model suggest that statin-induced myopathy is associated with the development of muscle insulin resistance, providing a potential mechanism." http://www.medpagetoday.com/Cardiology/Atherosclerosis/27197?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&userid=250294

4/23/11 Screen time damages eyes -- a link to heart disease. http://www.medpagetoday.com/Cardiology/Prevention/26071?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&userid=250294

Coffee and high-fat food together are bad news for blood sugar. http://www.diseaseproof.com/archives/diabetes-coffee-and-doughnuts-doubletrouble-for-diabetes-risk.html

4/18/11 Each 1 kg weight loss (2.2 pounds) was associated with a 0.39 mm Hg decrease in systolic and 0.26 mm Hg decrease in diastolic blood pressure, Marcello R.P. Markus, MD, PhD, of the University of Greifswald, Germany, and colleagues found in the population-based study of northeastern Germany. http://www.medpagetoday.com/MeetingCoverage/EuroPRevent/25981?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&userid=250294

4/6/11 Whether eating food or simply craving it, food lovers appear to have neural activity similar to that of substance abusers. http://www.medpagetoday.com/Psychiatry/Addictions/25713?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&em=peggykraus@verizon.net

3/24/11 While caloric restriction alone and caloric restriction plus exercise bring weight loss, total fat loss, visceral fat loss, and decrease systolic blood pressure, only caloric restriction and exercise together result in significant improvements in diastolic blood pressure (bottom number), LDL cholesterol, and insulin sensitivity, caloric restriction only does not. http://www.diseaseproof.com/archives/exercise-caloric-restriction-even-better-with-exercise.html

3/12/11  After adjustment for age, sex, and smoking status, the researchers found that BMI, waist circumference, and waist-to-hip ratio were all associated with cardiovascular event risk to a similar degree. http://www.medpagetoday.com/PrimaryCare/Obesity/25291?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&em=peggykraus@verizon.net

12/29/10 Several recent studies have identified unique responses to exercise testing that help distinguish patients with obstructive sleep apnea. These include blunted heart rate and exaggerated ventilatory response during the GXT and blunted heart rate recovery during the early post-exercise minutes.

12/29/10 Estrogens do not appear to impart muscle strength by making more contractile machinery or by making muscle fibers larger (as androgens -- anabolic steroids -- do), but rather by making those fibers and the force-generating molecules within them functionally better. While our data support estrogens’ qualitative influences, an anabolic role for these hormones shouldn’t be dismissed. The cattle industry has used low-level estrogens to enhance muscle quantity, i.e., beef production, for decades. http://www.multibriefs.com/briefs/acsm/active6-29.htm

12/28/10 Strength exercise lessens the oxygen demand of the heart at submaximal workloads, promotes bone health, increases flexibility and joint mobility, and helps prevent falls. http://www.multibriefs.com/briefs/acsm/active7-6.htm

12/28/10 Using energy drinks can raise pleasure-reward thresholds and damage neurotransmitter receptor sites. This results in more drug craving and/or thrill-seeking to satisfy homeostatic brain deficiencies and increases the chances of developing anxiety and depressive disorders. Energy drink use significantly predicts increased alcohol use, the illicit use of amphetamines (Adderall), and risk-taking such drinking and driving.http://www.multibriefs.com/briefs/acsm/active8-17.htm

12/27/10 A grain-based vegetarian diet may be better than a meat-based diet in terms of holding down phosphorus levels and raising parathyroid levels in patients with chronic kidney disease. http://www.medpagetoday.com/Nephrology/GeneralNephrology/24060?utm_content=GroupCL&utm_medium=email&impressionId=1293437338359&utm_campaign=DailyHeadlines&utm_source=mSpoke&userid=250294

10/7/10  Watercress is rich in a specific glucosinolate called gluconasturtiin, which is a precursor to the ITC phenethyl isothiocyanate (PEITC). PEITC in watercress was also found to reduce tumor cell survival and decrease the action of hypoxia-inducible factor (HIF), which is a molecule that stimulates angiogenesis (blood vessel development), allowing a tumor to obtain a blood supply.

A new study has investigated the effects of watercress on HIF activity in human subjects. Hypoxia (low oxygen levels) is a key stimulus for tumor growth – as a tumor grows, its oxygen and nutrient needs exceed those that it can receive by diffusion from adjacent healthy tissue. When tumor cells sense hypoxia, they send angiogenic signals to surrounding normal tissue in order to obtain a direct blood supply. HIF is an essential part of this process, activating the production of angiogenic proteins, consequently promoting tumor growth.http://www.diseaseproof.com/archives/cancer-anticancer-properties-of-watercress.html

9/15/10 Taking aspirin daily or every other day increases the risk for hemorraghic stroke, gastrointestinal problems including ulcers and bleeding and does not reduce the risk of dying from a heart attack. Joel Fuhrman, MD. Healthy Times, December 2002.

9/9/10  Nonstick Cookware May Raise Kids' Cholesterol. Arch Pediatr Adolesc Med. 2010;164(9):860-869. doi:10.1001/archpediatrics.2010.163. http://archpedi.ama-assn.org/cgi/content/short/164/9/860

9/9/10 Low-Carb Diet is Better When Rich in Veggies. Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality. http://www.annals.org/content/153/5/289.abstract

8/22/10  Insulin increases the oils that appear on our skin. Insulin levels affect other hormones such as testosterone that also promote acne.http://www.diseaseproof.com/archives/acne-radiant-skin-101.html

Subjects who consumed 74 grams (roughly 2 ½ twenty-ounce soft drinks or 13 bananas) or more of fructose each day in added sugar increased their risk of blood pressure elevated above 135/85 by 26%, above 140/90 by 30%, and above 160/100 by 77%.4 http://www.diseaseproof.com/archives/blood-pressure-fructose-from-added-sugars-linked-to-high-blood-pressure.html

Sucrose intake, fructose intake, and high glycemic load have all been associated with pancreatic cancer in epidemiological studies, and diabetes also increases risk.5,6  http://www.diseaseproof.com/archives/cancer-fructose-fuels-cancer-cell-growth.html

6/30/2010 Estrogen, like androgen, can increase muscle strength. Estrogen replacement and supplementation does play a role in the improvement of muscle performance. Unlike the anabolic effect of androgens as steroid hormones to increase size and number of muscle fibers, estrogen increases functional capacity and the force-generating capacity of existing fibers. www.multibriefs.com/briefs/acsm/active6-29.htm

6/12/10  Reducing intake of sugar-sweetened beverages gives better BP control. These findings support the recommendation to avoid sweetened drinks as one component of reducing risk of cardiovascular risk factors such as blood pressure. http://www.cardiosource.com/cjrpicks/CJRPick.asp?cjrID=5923

Study Shows Greater Risk of Heart Attacks and Earlier Death for Short People.

Short stature increased the risk of heart disease illness and death by 1.5 times.
Short men had a 37% increased risk for dying from any cause, and short women a 55% increased risk.
Both short men and short women had a 52% increased risk of having a heart attack. http://www.cardiosmart.org/News/Default.aspx?id=3417

5/29/10 Exercise May Keep Cancer Patients Healthier During, After Treatment. Breast and prostate cancer patients who regularly exercise during and after cancer treatment report having a better quality of life and being less fatigued. Henry Ford Health System (2010, May 22). Exercise may keep cancer patients healthier during, after treatment. ScienceDaily. Retrieved May 29, 2010, from http://www.sciencedaily.com­ /releases/2010/05/100520213110.htm


Traditional aerobic fitness training trumps pedometer-based walking programs for health benefits.http://www.eurekalert.org/pub_releases/2010-05/uoa--taf051110.php.

Risk of incontinence linked to high calorie and high-saturated fat content diet, regardless of body weight.  American Journal of Epidemiology, online April 25, 2010. http://aje.oxfordjournals.org/cgi/content/abstract/171/10/1116?%3C/p%3E

A high-fat diet might help fuel the inflammatory component of asthma, data from a small clinical study suggests. The fatty meal also significantly impaired bronchodilator response compared with asthma patients who consumed a low-fat meal (P=0.001). Wood L et al. "A high-fat challenge enhances innate immune responses in asthmatic airway" ATS 2010; Abstract A5182.http://www.medpagetoday.com/MeetingCoverage/ATS/20149?utm_content=GroupCL&utm_medium=email&impressionId=1274170903027&utm_campaign=DailyHeadlines&utm_source=mSpoke&userid=250294

5/15/2010 Consuming more nuts appears to be associated with improvements in blood cholesterol levels. Nuts are rich in plant proteins, fats (especially unsaturated fatty acids), dietary fiber, minerals, vitamins and other compounds, such as antioxidants and phytoesterols. Arch Intern Med. 2010;170(9):821-827. http://archinte.ama-assn.org/cgi/content/short/170/9/821

Whole grains, especially fiber- and vitamin-rich bran, may protect the heart by reducing inflammation in the body. http://circ.ahajournals.org/cgi/content/abstract/CIRCULATIONAHA.109.907360v1

Eating peppers increases food-induced heat production. The compound DCT found in peppers, even the not-hot-varieties, significantly increased fat oxidation, pushing the body to use more fat as fuel. http://www.sciencedaily.com/releases/2010/04/100427190934.htm

A component in a layer of tissue surrounding grains of brown rice may work against angiotensin II. Angiotensin II is an endocrine protein and a known culprit in the development of high blood pressure and atherosclerosis. http://www.the-aps.org/press/releases/10/13.htm

3/18/2010 Strengthening muscles has been shown to be the most effective way to strengthen bone and protect against osteoporosis-related fractures.1 Compared to exercise, medications are relatively ineffective and may cause harm.

Joel Fuhrman, MD,. Women taking Fosamax for several years may be prone to femur fractures.

1Rubin C, Turner AS, Muller R, et al. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Min Res 2002;17:349-357.

9/8/2009 The incidence and severity of multiple sclerosis (MS) increases with animal food (especially cow's milk product) consumption.

The China Study, T. Colin Campbell, PhD.


The obesity epidemic in the US is due solely to increased food intake



Return of the J-curve: TNT analysis shows that BP can be too low in CAD patient

Optimal BP may be approximately 112/72 mm Hg. Diastolic BP below 60 mm Hg causes an underperfusion of the coronary arteries during diastole, which in turn increases the risk of MI. Also, low diastolic blood pressure results in high pulse pressures, which leads to endothelial dysfunction, stiff arteries, and vascular disease. It is also possible there is “reverse causation” at play in that patients with low blood pressure might actually be sicker patients.



Big Men and Atrial Fibrillation: Effects of Body Size and Weight Gain on Risk of Atrial Fibrillation in Men

(probably results from increased atrial size )



Does dual antiplatelet therapy increase infection risk http://www.theheart.org/article/965813.do

HR increase prior to exercise is strong predictor for SChttp://www.theheart.org/article/966049.do


Meta-analysis supports heart-health benefits from a Mediterranean diet



LDL cholesterol levels lowest in summer, highest in winter.



Studies of whether bisphosphonates (osteoporosis meds) are linked to arrhythmia are split.  It is recommended that those taking these drugs and who have a history of rhythm irregularity use the drugs with caution. Better yet, make dietary changes to support bone health — cut down significantly on dairy and other animal foods.



FDA advisory panel votes unanimously in favor of prasugrel– alternative to plavix;  increase cancer risk, elderly/frail to take smaller dose.


Majority of patients hospitalized with CAD at guideline-recommended LDL targets


“One of the major findings of this study that should serve as a wake-up call for anyone interested in reducing death and disability due to cardiovascular disease is that nearly 75% of patients having first ACS events had LDL levels below 130 mg/dL, and nearly 50% had LDL levels below 100 mg/dL.”